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Target intelligence / Profile preview
Tumor-Associated Antigens in Hepatocellular Carcinoma (TAAs)
- Target
- TAAs
- Molecular classification
- Protein, Glycoprotein
01
Overview
Tumor-associated antigens (TAAs) in hepatocellular carcinoma (HCC) are proteins or other molecular structures that are overexpressed or aberrantly expressed on the surface of HCC cells compared to normal liver tissue. These antigens, including Glypican-3 (GPC3), Alpha-fetoprotein (AFP), Annexin-A2, and MAGE-C1/C2, serve as key targets for immunotherapeutic strategies, including cancer vaccines and adoptive T cell therapies, due to their ability to elicit tumor-specific immune responses. High TAA expression often correlates with aggressive disease features and poor prognosis.
- Other names
- Hepatocellular Carcinoma AntigensHCC AntigensCancer Antigens in HCC
02
Mechanism of action
Various, including induction of cytotoxic T-cell responses, antibody-dependent cell-mediated cytotoxicity (ADCC), and blockade of immune checkpoints.
03
Biological functions
Cell proliferationImmune responseSignal transduction
04
Disease associations
CancerHepatocellular carcinomaTumor progression
05
Safety considerations
Immune toleranceOn-target, off-tumor toxicityLimited efficacy of vaccines
06
Interacting drugs
Peptide vaccines
2 more in the full profile.
07
Biomarkers
Glypican-3 (GPC3)Alpha-fetoprotein (AFP)Annexin-A2MAGE-C1MAGE-C2WT1TERTSSX-2NY-ESO-1SALL4
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