Target intelligence / Profile preview

Tumor-associated calcium signal transducer 1 (EpCAM)

Target: EpCAM
Molecular classification: Type I membrane glycoprotein, Cell adhesion molecule

Overview

EpCAM is a type I transmembrane glycoprotein primarily expressed on the surface of epithelial cells and various carcinoma cells. It plays roles in cell adhesion, signaling, proliferation, differentiation, migration, and has oncogenic potential and is widely used as a marker and therapeutic target for epithelial-derived tumors.

Other names: Epithelial cell adhesion moleculeCD326TACSTD1

Mechanism of action

Targeted by monoclonal antibodies; inhibitors of cleavage/signaling.

Biological functions

Cell adhesionCell signalingCell proliferationCell differentiationCell migrationGene expression regulation

Disease associations

Cancer

Biomarkers

Circulating tumor cells

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