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Target intelligence / Profile preview
Tumor-associated calcium signal transducer 2 (TROP2)
- Target
- TROP2
- Molecular classification
- EPCAM family, Type I cell surface transmembrane glycoprotein receptor
01
Overview
Trop‑2/TACSTD2 is a single-pass type I membrane glycoprotein receptor that acts both as a marker for carcinoma cells and an active participant driving tumorigenesis through calcium-mediated signal transduction pathways. Its unique structure-function relationships make it both diagnostically valuable and therapeutically actionable across multiple human cancers.
- Other names
- EGP-1GA733-1Trop-2TACSTD2
02
Mechanism of action
Antibody-drug conjugates target TROP2 expressing cells, delivering a cytotoxic payload upon internalization.
03
Biological functions
Maintenance of epithelial tissue integrityCell-cell communicationCell adhesionCalcium signal transductionOncogenic signalingCell proliferationCell survivalCell migrationCell invasion
04
Disease associations
Cancer progressionGelatinous drop-like corneal dystrophy
05
Safety considerations
Potential toxicities associated with antibody-drug conjugates, depending on the payload and off-target effects.
06
Interacting drugs
Sacituzumab govitecan
1 more in the full profile.
07
Biomarkers
TROP2 overexpression (prognostic biomarker for high-risk cancer patients)
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