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Target intelligence / Profile preview
Tumor-associated Epithelial Mucin 1 (MUC1)
- Target
- MUC1
- Molecular classification
- Transmembrane Mucin, Glycoprotein
01
Overview
MUC1 is a transmembrane mucin protein that is overexpressed and aberrantly glycosylated in many epithelial cancers. It plays a role in tumor progression by disrupting cell polarity, promoting EMT, and modulating signaling pathways. It is considered a potential biomarker and therapeutic target for cancer.
- Other names
- Epithelial Membrane AntigenEMAPolymorphic Epithelial MucinPEMCancer antigen CA15-3
02
Mechanism of action
MUC1-targeted therapies aim to disrupt its signaling pathways, inhibit its interaction with other proteins, or deliver cytotoxic agents specifically to MUC1-expressing cells.
03
Biological functions
Cell adhesionCell signalingEpithelial protectionRegulation of gene expression
04
Disease associations
CancerInflammation
05
Safety considerations
Off-target effects due to MUC1 expression in normal tissuesDevelopment of resistance to MUC1-targeted therapiesImmunogenicity of MUC1-based vaccines
06
Biomarkers
CA15-3MUC1 expression levels in tumor tissueSoluble MUC1 in serum
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