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Tumor-associated macrophage M2 polarization (None)
- Target
- None
- Molecular classification
- Cellular process, Macrophage polarization, Immune cell regulation
01
Overview
Tumor-associated macrophage (TAM) M2 polarization refers to the differentiation of macrophages within the tumor microenvironment (TME) into an alternatively activated (M2) phenotype. This polarization is driven by factors such as IL-4, IL-13, IL-10, TGF-β, and CSF1/M-CSF. M2-polarized TAMs exhibit pro-tumoral functions, including immune suppression, angiogenesis promotion, and tissue remodeling, ultimately contributing to tumor growth, metastasis, and drug resistance. Targeting TAM M2 polarization is a promising therapeutic strategy for cancer.
- Other names
- TAM M2 polarizationM2 macrophage polarization in tumorsTumor-associated macrophage alternative activation
02
Mechanism of action
Reprogramming TAMs from M2 to M1 phenotype; Inhibiting M2 polarization; Blocking recruitment of monocytes/macrophages to the tumor; Inhibiting survival signals for macrophages in tumors
03
Biological functions
Immune suppressionAngiogenesis promotionTissue remodelingExtracellular matrix remodelingTumor promotionMetastasisDrug resistance
04
Disease associations
CancerTumor microenvironment
05
Safety considerations
Off-target effects on other macrophage populationsPotential for systemic immune activationDevelopment of resistance to repolarization strategiesCytokine storm
06
Interacting drugs
CSF1R inhibitors
3 more in the full profile.
07
Biomarkers
CD163 expressionCD206 expressionArginase-1 expressionIL-10 levelsTGF-β levelsVEGF levels
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