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Target intelligence / Profile preview
Tumor-Associated Mucin 1 (MUC1)
- Target
- MUC1
- Molecular classification
- Type I transmembrane mucin
01
Overview
Mucin 1 (MUC1) is a high-molecular-weight, highly glycosylated type I transmembrane protein normally expressed on epithelial cells. In cancer, MUC1 undergoes aberrant expression (overexpression and hypoglycosylation), promoting proliferation, invasion, metastasis, and drug resistance. It is a diagnostic and prognostic marker and a therapeutic target for immunotherapy.
- Other names
- TA-MUC1Mucin 1MUC-1CA 15-3 (soluble form)
02
Mechanism of action
Targeting aberrantly glycosylated MUC1 to elicit cytotoxic T lymphocyte responses and antibody-dependent cellular cytotoxicity (ADCC)
03
Biological functions
Cell proliferationCell survivalMetastatic invasionCell adhesion modulationSignal transductionBarrier function (normal)Lubrication (normal)
04
Disease associations
CancerTumor progressionMetastasisDrug resistance
05
Safety considerations
Potential for off-target effects due to MUC1 expression in normal tissuesDevelopment of resistance to MUC1-targeted therapiesChallenges in achieving sufficient tumor-specific targeting
06
Biomarkers
CA 15-3 (breast cancer diagnosis)MUC1 expression levels (prognosis in pancreatic cancer)
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