Tumor-associated myeloid-derived suppressor cell (MDSC (for Myeloid-derived suppressor cell))

Tumor-associated myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that accumulate in the tumor microenvironment and contribute to immune tolerance by inhibiting CD8+ T-cell function. Depletion or modulation of these cells is considered a therapeutic strategy in cancer immunotherapy. Agents such as 5-fluorouracil have been shown to selectively kill MDSCs without significantly affecting other immune populations, thereby enhancing antitumor immunity through increased interferon-gamma production by CD8+ T-cells and promoting an anti-tumoral microenvironment[1][2]. The efficacy of this approach can depend on factors such as STING pathway activation within cancer cells, which influences type I interferon production and subsequent effects on both intratumoral T-cells and myeloid populations[2].

Other names

Myeloid-derived suppressor cellMDSCtumor-associated myeloid celltumor-infiltrating myeloid cell

Selective cytotoxicity to MDSCs leading to their depletion and enhanced antitumor T-cell responses[1][2]