Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Tumor-associated NADH oxidase (ENOX2)
- Target
- ENOX2
- Molecular classification
- Enzyme, Oxidase, Protein disulfide isomerase
01
Overview
Tumor-associated NADH oxidase (ENOX2), also known as ecto-NOX disulfide-thiol exchanger 2 or tNOX, is a dimeric protein containing four copper atoms per dimer. It functions as a terminal oxidase in plasma membrane electron transport, catalyzing the oxidation of NADH to NAD+. ENOX2 activity oscillates with a period of about 24 minutes under normal conditions. The tumor-specific splice variant tNOX is found on the surface of many human cancers but not on most normal cells and is constitutively active. It is a potential pan-cancer biomarker and therapeutic target.
- Other names
- Ecto-NOX disulfide-thiol exchanger 2tNOX
02
Mechanism of action
Selective inhibition of tNOX activity in cancer cells, leading to anti-cancer effects.
03
Biological functions
Oxidation of NADH/NAD(P)HProtein disulfide-thiol exchangeCell growth regulationBiological clock regulation
04
Disease associations
Cancer
05
Safety considerations
Selectivity for tNOX over native forms (CNOX/ENOX1, arNOX) is crucial to avoid off-target effects.
06
Interacting drugs
Phenoxodiol
4 more in the full profile.
07
Biomarkers
tNOX/ENOX2 expression in tumor tissuetNOX/ENOX2 levels in serum
Beyond the preview
Go deeper on Tumor-associated NADH oxidase (ENOX2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Tumor-associated NADH oxidase (ENOX2).