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Target intelligence / Profile preview
Tumor-Associated Peptide Antigens (TAAs)
- Target
- TAAs
- Molecular classification
- Peptide, Protein, Glycoprotein, Antigen
01
Overview
Tumor-associated peptide antigens (TAAs) are molecules, often peptides or proteins, present at elevated levels on tumor cells but may also be found at lower levels on normal cells. They are recognized by the immune system and can serve as targets for diagnostic tests and therapeutic interventions, including monoclonal antibodies and cancer vaccines. While effective in some cases, challenges remain due to potential off-target effects and immune tolerance.
- Other names
- Tumor-associated antigensTAATumor-associated peptideCancer antigens
02
Mechanism of action
Antibody-dependent cellular cytotoxicity (ADCC), T-cell mediated cytotoxicity, Immune checkpoint modulation, Direct tumor cell killing
03
Biological functions
Immune recognitionTumor cell surface presentationT-cell activationTarget for antibody binding
04
Disease associations
CancerTumor growthImmune evasion
05
Safety considerations
Off-target effects due to expression in normal tissuesImmune-related adverse eventsTumor escape mechanismsLimited efficacy due to immune tolerance
06
Interacting drugs
Rituximab
3 more in the full profile.
07
Biomarkers
HER2/neuEGFRMUC1PSACEAWT1
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