Tumor-associated Proteobacteria

**Tumor-associated Proteobacteria** are bacteria from the Proteobacteria phylum that inhabit tumor tissues across various cancer types, often at higher abundance and diversity compared to adjacent normal tissues[1][2][3][4]. These bacteria influence the tumor microenvironment by modulating immune responses, driving metabolic reprogramming, and promoting or suppressing processes such as epithelial-mesenchymal transition, proliferation, and metastasis[1][3][4]. The composition and role of Proteobacteria in tumors is highly context-dependent, varying by cancer type, tissue origin, and host factors. While not a classical molecular target, their compositional shifts can serve as potential biomarkers for prognosis or guide the development of microbiota-based cancer therapies. However, "Tumor-associated Proteobacteria" is a collective term rather than a discrete target, making its designation as a therapeutic target problematic[2][3][4].

Other names

Intratumoral ProteobacteriaTumor microbiota ProteobacteriaProteobacterial phylum in cancerMicrobiota-associated Proteobacteria in tumors