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Target intelligence / Profile preview
Tumor-associated surface antigen recognized by OneCAR scFv (OneCAR Target)
- Target
- OneCAR Target
- Molecular classification
- Receptor, Surface Antigen, Glycoprotein
01
Overview
- Other names
- OneCAR adapter targetOneCAR switch targetUniversal CAR targetMulti-targeting CAR antigen
02
Mechanism of action
The OneCAR scFv recognizes a specific adapter molecule (targeting module) that bridges the CAR-T cell to a tumor-associated surface antigen, inducing T-cell activation and tumor cell lysis.
03
Biological functions
Cell signalingCell adhesionImmune recognition
04
Disease associations
CancerSolid tumorsAcute myeloid leukemia (AML)
05
Safety considerations
On-target/off-tumor toxicityCytokine release syndrome (CRS)NeurotoxicityAntigen loss/escape
06
Interacting drugs
ARO201
2 more in the full profile.
07
Biomarkers
GPC3 expressionHER2 expressionEGFR expressionCLL-1 expression
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