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Target intelligence / Profile preview
Tumor Blood Vessel Antigen
- Molecular classification
- Cell surface antigen, Protein
01
Overview
Tumor blood vessel antigens are antigens specifically or preferentially expressed on the endothelial cells of blood vessels within tumors, as opposed to normal vasculature. They are key components in the tumor microenvironment and play a central role in tumor growth, metastasis, immune evasion, and response to therapy. Targeting these antigens is a strategy for cancer therapy.
- Other names
- Tumor-associated endothelial antigenTumor vasculature antigen
02
Mechanism of action
Inhibition of angiogenesis; normalization of tumor vasculature; enhanced immune cell infiltration
03
Biological functions
AngiogenesisRegulation of vascular structure/functionModulation of local immunityTumor growthMetastasis
04
Disease associations
CancerTumor microenvironment
05
Safety considerations
Off-target effects on normal vasculatureDevelopment of resistanceImmune-related adverse events
06
Interacting drugs
Antiangiogenic agents
2 more in the full profile.
07
Biomarkers
Expression levels on tumor endothelial cellsChanges in tumor vascular densityPerfusion measurements
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