Tumor cell (via preserved anti-tumor cytotoxicity)

The term "tumor cell (via preserved anti-tumor cytotoxicity)" refers to targeting tumor cells by maintaining or enhancing the cytotoxic functions of immune effector cells (T lymphocytes and NK cells) capable of recognizing and killing cancer cells. This approach is central to many immunotherapies, which aim to preserve or boost the body's natural ability to eliminate tumor cells. Key strategies involve blocking inhibitory checkpoint receptors, enhancing co-stimulatory signals, or adoptive transfer of engineered immune cells with preserved cytolytic function.

Other names

Tumor cells sensitive to T-cell mediated killingTumor cells susceptible to NK cell-mediated killingTumor cells targeted by immune effector cells

Enhancement or preservation of cytotoxic T lymphocyte (CTL) and NK cell-mediated killing of tumor cells, often through blockade of inhibitory checkpoints or adoptive transfer of engineered immune cells.