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Tumor Cell Apoptosis Pathway
- Molecular classification
- Signaling pathway, Regulatory network
01
Overview
The tumor cell apoptosis pathway refers to the molecular mechanisms by which cancer (tumor) cells undergo programmed cell death. Dysregulation of these pathways allows tumor cells to evade death and continue proliferating. Key pathways include the intrinsic (mitochondrial) and extrinsic (death receptor-mediated) pathways. Many anticancer therapies aim at reactivating these pathways.
- Other names
- Apoptosis pathway in cancer cellsProgrammed cell death in tumorsIntrinsic apoptosis pathwayExtrinsic apoptosis pathway
02
Mechanism of action
Various, including induction of DNA damage, inhibition of anti-apoptotic proteins, and activation of death receptors.
03
Biological functions
ApoptosisCell deathTumor suppressionRegulation of cell proliferation
04
Disease associations
CancerDrug resistance
05
Safety considerations
Resistance mechanismsOff-target effectsTumor heterogeneity
06
Interacting drugs
Chemotherapy drugs
4 more in the full profile.
07
Biomarkers
p53 statusBCL‑2 expression levelsDeath receptor expression levels
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