Tumor cell-associated antigen

“Tumor cell-associated antigen” is a general term describing any antigen that is present on the surface of tumor cells. Tumor antigens are generally divided into two categories: tumor-specific antigens (TSAs), unique to cancer cells, and tumor-associated antigens (TAAs), which are present at higher levels in tumor cells but may also be found in some normal tissues[1][2][3]. Examples of antigens in this class include mutated proteins (e.g., mutant p53), proteins overexpressed in tumors, oncoviral proteins, and oncofetal antigens. These antigens are important in immuno-oncology as therapeutic targets, but the term itself does not refer to a single molecular entity and as such cannot provide structured target information for drug discovery[1][2][3][4]. Important Note: - This entry is not specific to a single gene or protein, and many different tumor antigens exist (such as MAGE, PRAME, or HER2), each of which requires its own structured data entry. “Tumor cell-associated antigen” is conceptually correct but not appropriate as a single-drug development target[1][2][3]. - If you seek structured information on a specific antigen, such as “Melanoma-associated antigen 1 (MAGEA1)” or “Epidermal growth factor receptor (EGFR),” these should be addressed individually.

Other names

Tumor antigenTumor-associated antigenTumor-specific antigenTAATSA