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Tumor cell irradiation by beta-emitting yttrium-90 microsphere deposition in hepatic vasculature (Y-90 Radioembolization)

Target
Y-90 Radioembolization
Molecular classification
Other
01

Overview

This procedure involves the deposition of beta-emitting yttrium-90 microspheres into the hepatic vasculature to irradiate tumor cells. It is a minimally invasive treatment that combines embolization with radiation therapy to target liver tumors, particularly for inoperable cases. The microspheres emit radiation over a short period, leading to tumor cell death while minimizing damage to surrounding healthy tissue.

Other names
Y-90 RadioembolizationSelective Internal Radiation Therapy (SIRT)Radioembolization
02

Mechanism of action

Delivery of beta radiation directly to tumors via microspheres. Blocking blood supply to tumors. Inducing cell death in tumor cells while sparing healthy tissue.

03

Biological functions

Cell deathApoptosis
04

Disease associations

Cancer
05

Safety considerations

Potential for allergic reactions to materials used.Risk of infection at the catheter site.Possible gastrointestinal ulcers if microspheres lodge in unintended areas.Radiation pneumonitis.
06

Biomarkers

alpha-fetoprotein (AFP) levels

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