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Target intelligence / Profile preview
Tumor Cell Lysis via Oncolytic Adenovirus Infection (OAd-mediated Tumor Lysis)
- Target
- OAd-mediated Tumor Lysis
- Molecular classification
- Viral Therapy, Immunotherapy
01
Overview
Tumor cell lysis via oncolytic adenovirus infection is a cancer therapy approach that utilizes engineered or naturally occurring adenoviruses to selectively infect, replicate within, and destroy cancer cells, leading to both direct cytolysis and stimulation of antitumor immunity.
- Other names
- Oncolytic Adenovirus TherapyAdenoviral VirotherapyOAd-mediated Cytolysis
02
Mechanism of action
Oncolytic adenoviruses selectively infect and replicate within cancer cells, leading to cell lysis and release of tumor-associated antigens, which in turn stimulate an antitumor immune response.
03
Biological functions
Tumor cell deathImmune stimulationAntigen releaseInflammation
04
Disease associations
Cancer
05
Safety considerations
Off-target effectsImmune-related adverse eventsPotential for viral sheddingPre-existing anti-adenoviral immunity
06
Interacting drugs
OAds expressing GM-CSF
2 more in the full profile.
07
Biomarkers
Expression of CAR/CXADRStatus of p53 pathwayStatus of retinoblastoma pathwayTumor-associated antigensNeoantigens
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