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Target intelligence / Profile preview
Tumor Cell Lysis via Oncolytic Viral Infection (OV-mediated Tumor Lysis)
- Target
- OV-mediated Tumor Lysis
- Molecular classification
- Viral therapy, Immunotherapy
01
Overview
Tumor cell lysis via oncolytic viral infection is a therapeutic strategy that utilizes specifically selected or engineered viruses (oncolytic viruses, OVs) to infect and destroy cancer cells. OVs exploit unique features of tumor cells, such as altered surface receptors, defective antiviral responses, and abnormal signaling pathways, to selectively replicate within and lyse malignant cells while sparing normal tissue. The therapy induces both direct oncolysis and activation of anti-tumor immunity.
- Other names
- Oncolytic Virus TherapyOV TherapyViral OncolysisCancer Cell Lysis by VirusTumor Destruction by Oncolytic Virus
02
Mechanism of action
Direct oncolysis (tumor cell lysis due to viral replication) and immune activation (release of tumor antigens and stimulation of innate and adaptive immunity).
03
Biological functions
Tumor cell deathImmune system activationAntigen releaseCell lysisViral replication
04
Disease associations
Cancer
05
Safety considerations
Off-target effects in normal tissuesAnti-viral immune response limiting efficacyPotential for viral shedding and transmissionInsertional mutagenesis (for integrating viruses)Cytokine release syndromePre-existing immunity to the virus
06
Interacting drugs
Oncolytic viruses (e.g., Talimogene laherparepvec, Adenoviruses)
4 more in the full profile.
07
Biomarkers
Tumor-specific antigensExpression levels of viral receptors on tumor cellsImmune cell infiltration in tumor microenvironmentViral load in tumor tissuePre-existing anti-viral immunityPD-L1 expression
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