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Target intelligence / Profile preview
Tumor Cell Lysis via Viral Infection (Oncolysis)
- Target
- Oncolysis
- Molecular classification
- Virus, Infectious agent, Therapeutic strategy
01
Overview
Tumor cell lysis via viral infection refers to the process by which viruses, particularly oncolytic viruses (OVs), selectively infect and destroy cancer cells. This approach exploits the unique vulnerabilities of tumor cells to viral replication, leading to direct cell death (oncolysis) and stimulation of antitumor immune responses.
- Other names
- Oncolytic VirotherapyViral-mediated Cancer Cell DestructionOV Therapy
02
Mechanism of action
Direct lysis of tumor cells by viral replication; induction of antitumor immune response.
03
Biological functions
Cell deathImmune response stimulationTumor regression
04
Disease associations
Cancer
05
Safety considerations
Off-target toxicityAnti-viral immune responseInsertional mutagenesisPotential for viral evolution
06
Biomarkers
Viral loadTumor antigen releaseImmune cell infiltrationInterferon signaling statusExpression of viral receptors on tumor cells
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