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Tumor Cell Lysis via Viral Oncolysis
- Molecular classification
- Virus, Therapeutic strategy
01
Overview
Tumor cell lysis via viral oncolysis refers to the process by which oncolytic viruses (OVs) selectively infect, replicate within, and destroy cancer cells. This mechanism exploits the unique vulnerabilities of tumor cells—such as defective antiviral responses and altered surface receptors—allowing OVs to preferentially target malignant tissue while sparing normal cells. Effectiveness stems from both direct destruction of infected tumor cells and stimulation/modulation of host immune responses against residual disease.
- Other names
- Oncolytic virotherapyViral oncolysis
02
Mechanism of action
Direct lysis of tumor cells by viral replication and induction of anti-tumor immunity.
03
Biological functions
Tumor cell lysisImmune stimulationAntigen presentationT-cell activationVascular disruption
04
Disease associations
Cancer
05
Safety considerations
Off-target effectsImmune-related adverse eventsViral sheddingDevelopment of anti-viral immunity
06
Interacting drugs
T-VEC
1 more in the full profile.
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