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Target intelligence / Profile preview
Tumor Cell NKG2D Ligands (NKG2DLs)
- Target
- NKG2DLs
- Molecular classification
- MHC-like proteins, Cell surface receptor ligands
01
Overview
NKG2D ligands (NKG2DLs) are a family of stress-induced cell surface molecules that are recognized by the activating immune receptor NKG2D. They are typically upregulated on tumor cells and trigger NK cell and T cell-mediated cytotoxicity. The main families include MICA/B and ULBP1-6. Tumor cells can evade immune detection by shedding soluble forms of NKG2DLs, which can impair antitumor immunity. Targeting the NKG2D/NKG2DL axis is an active area in cancer immunotherapy.
- Other names
- MICAMICBULBP1ULBP2ULBP3ULBP4ULBP5ULBP6RAET1 family members
02
Mechanism of action
Enhance ligand expression/stability; Block ligand shedding; CAR-T/CAR-NK therapies targeting NKG2D ligands
03
Biological functions
Immune cell activationTarget cell recognitionRegulation of cytotoxicityStress response signaling
04
Disease associations
CancerViral infectionAutoimmunity
05
Safety considerations
Off-tumor toxicity due to expression in healthy tissuesImmune-related adverse eventsCytokine release syndrome
06
Biomarkers
NKG2D ligand expression levels in tumor tissueSoluble NKG2D ligand levels in serum
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