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Target intelligence / Profile preview
Tumor Cell Nuclear DNA (DNA)
- Target
- DNA
- Molecular classification
- Nucleic Acid, DNA
01
Overview
Tumor cell nuclear DNA is the genetic material within cancer cells that serves as the target for beta particle emission from radionuclide-loaded microspheres. The localized radiation induces irreparable DNA damage, leading to cell death and tumor regression. Selectivity is achieved via targeted delivery of the microspheres and the limited range of beta particles, minimizing damage to surrounding healthy tissues.
- Other names
- Cancer Cell DNAMalignant Cell DNANeoplastic Cell DNA
02
Mechanism of action
Induction of DNA double-strand breaks via beta particle emission leading to apoptosis or mitotic catastrophe.
03
Biological functions
Genetic Information StorageReplicationTranscriptionGenome Maintenance
04
Disease associations
CancerGenetic InstabilityTumorigenesis
05
Safety considerations
Off-target radiation exposureBone marrow suppressionLiver toxicity (for liver-directed therapies)Radiation-induced pneumonitisGastrointestinal side effects
06
Interacting drugs
Radioactive microspheres (^90Y, ^131I loaded)
1 more in the full profile.
07
Biomarkers
DNA damage markers (e.g., γH2AX)Cell cycle arrest markers (e.g., p21)Apoptosis markers (e.g., cleaved caspase-3)Tumor volume reduction
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