Tumor Cell Radiosensitization via Physical Enhancement of Radiation Energy Deposition

Strategies that increase the sensitivity of tumor cells to radiation therapy by physically enhancing the deposition of radiation energy within or near cancer cells, primarily through the use of high atomic number materials like gold nanoparticles or by leveraging the physical properties of particle therapy.

Other names

Nanoparticle-mediated radiosensitizationGold nanoparticle radiosensitizationParticle therapy radiosensitizationHigh-Z nanoparticle radiosensitizationPhysical dose enhancement for radiotherapy

Local amplification of ionizing events during radiotherapy, increased secondary electron generation, enhanced DNA damage within tumor cells