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Target intelligence / Profile preview
Tumor Cell Surface Antigen (TCSA)
- Target
- TCSA
- Molecular classification
- Protein, Glycoprotein, Peptide, Receptor
01
Overview
A tumor cell surface antigen is any molecule or protein expressed on the surface of tumor cells that can be recognized by the immune system. These antigens are either unique to cancer cells (tumor-specific antigens, TSAs) or are present at much higher levels on cancer cells compared to normal tissues (tumor-associated antigens, TAAs). They serve as markers for distinguishing tumor cells from healthy tissue and can trigger an immune response, making them key targets for immunotherapies.
- Other names
- Tumor-Specific AntigenTSATumor-Associated AntigenTAACancer Cell Surface Antigen
02
Mechanism of action
Binding to target antigen, immune cell activation, tumor cell lysis, signal transduction blockade
03
Biological functions
Immune recognitionCell signalingCell-cell interactionTumor growthMetastasis
04
Disease associations
CancerAutoimmune diseases
05
Safety considerations
On-target/off-tumor toxicityAntigen downregulationImmunogenicityCytokine release syndrome
06
Interacting drugs
Cetuximab
3 more in the full profile.
07
Biomarkers
CD19EGFRPresence/absence of specific antigensAntigen expression level
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