Tumor Cell Surface Receptor

Tumor cell surface receptors are biologically active molecules embedded in the plasma membrane of cancer cells. They function as binding sites for various ligands such as growth factors, cytokines, adhesion molecules, and immune checkpoint proteins. These receptors can be overexpressed or aberrantly expressed on tumor cells compared to normal tissues. They regulate key processes such as proliferation, survival, migration/invasion and immune modulation, and are prime targets for monoclonal antibody therapies, CAR-T cell therapies, small molecule inhibitors, and tumor imaging agents.

Activation of downstream signaling pathways upon ligand binding or antibody engagement, influencing cellular behavior