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Target intelligence / Profile preview
Tumor cell targeting via heptamethine carbocyanine dye uptake mechanism
- Molecular classification
- Uptake mechanism, Dye-mediated targeting, OATP-dependent uptake
01
Overview
Heptamethine carbocyanine dyes (HMCDs) are near-infrared fluorescent compounds that are preferentially taken up by tumor cells due to factors like upregulated OATP transporters, tumor hypoxia-induced HIF-1α activation, and the EPR effect. This selective uptake is exploited for tumor imaging and targeted drug delivery.
- Other names
- HMCD uptakeIR-783 targetingMHI-148 targetingDZ-1 targetingPC-1001 targetingHeptamethine carbocyanine dye targetingNIR dye tumor targeting
02
Mechanism of action
OATP-mediated uptake, HIF-1α dependent upregulation of OATPs, Enhanced Permeability and Retention (EPR) effect, Mitochondrial membrane potential
03
Biological functions
Tumor cell uptakeDrug deliveryDiagnostic imagingPhotothermal therapy
04
Disease associations
Cancer
05
Safety considerations
Off-target toxicityPotential for dye accumulation in normal tissuesPhototoxicity
06
Interacting drugs
IR-783
5 more in the full profile.
07
Biomarkers
OATP1B3 expressionHIF-1α activityTumor hypoxia
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