Tumor cell uptake of boronated amino acids (BPA Uptake)

Tumor cell uptake of boronated amino acids, particularly boronophenylalanine (BPA), is a crucial process for Boron Neutron Capture Therapy (BNCT). This targeted therapy relies on the selective accumulation of boron-containing compounds within tumor cells, facilitated primarily by the L-type amino acid transporter 1 (LAT1), which is frequently overexpressed in various cancers. Once inside the cell, these boron compounds enable targeted destruction upon neutron irradiation. Achieving high tumor-to-normal tissue ratios is critical for efficacy, and variable LAT1 expression represents a challenge for broader application of this strategy.

Other names

Boronophenylalanine uptakeBPA accumulationBoron delivery to tumorsLAT1-mediated BPA transport

Active transport of boronated amino acids into tumor cells via overexpressed L-type amino acid transporter 1 (LAT1), leading to selective accumulation and subsequent cell death upon neutron irradiation in Boron Neutron Capture Therapy (BNCT).