Tumor cells expressing L523S mutation (L523S Tumor Cells)

Tumor cells expressing the L523S mutation represent a specific target for cytotoxic T lymphocytes (CTLs). The L523S mutation results in the presentation of a novel peptide antigen by MHC-I molecules on the tumor cell surface, which can be recognized by CTLs. This interaction triggers CTL activation and subsequent killing of the tumor cell through mechanisms such as perforin/granzyme release and Fas/FasL interaction. The effectiveness of this response is modulated by factors such as the density of antigen-specific CTLs, the expression level of L523S, and the presence of immunosuppressive factors within the tumor microenvironment.

Other names

L523S mutant tumor cellsTumor cells with L523S substitutionCancer cells expressing L523S

Targeted for lysis by cytotoxic T lymphocytes (CTLs) through recognition of L523S-derived peptides presented on MHC-I.