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Target intelligence / Profile preview
Tumor-Infiltrating Lymphocytes (TIL)
- Target
- TIL
- Molecular classification
- Immune cell subset, T cells (CD8+ cytotoxic, CD4+ helper), B cells
01
Overview
Tumor-infiltrating lymphocytes (TILs) are a subset of white blood cells, primarily T cells and B cells, that have migrated into tumor tissue. They play a crucial role in recognizing and killing cancer cells within the tumor microenvironment. TIL therapy involves isolating, expanding, and reinfusing these lymphocytes to enhance the patient's anti-tumor immune response. High TIL density and activation are often associated with better prognosis in certain cancers.
- Other names
- Tumour-infiltrating lymphocytes
02
Mechanism of action
Adoptive cell transfer therapy involving ex vivo expansion and reinfusion to enhance anti-tumor immune response.
03
Biological functions
Anti-tumor immunityTargeting and killing cancer cellsImmune responseAdaptive immunity
04
Disease associations
Cancer
05
Safety considerations
Potential for cytokine release syndromeAutoimmunityGraft-versus-host disease
06
Interacting drugs
Interleukin-2 (IL-2)
1 more in the full profile.
07
Biomarkers
TIL densityTIL activation state
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