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Target intelligence / Profile preview
Tumor Necrosis Factor Alpha (Soluble) (sTNFα)
- Target
- sTNFα
- Molecular classification
- Cytokine, Signaling molecule
01
Overview
Soluble Tumor Necrosis Factor Alpha (sTNFα) is a pro-inflammatory cytokine and a key mediator in immune system signaling. It plays central roles in inflammation, infection control, autoimmunity, and anti-tumor responses. sTNF is derived from the membrane-bound precursor form through enzymatic cleavage by TACE (ADAM17). sTNF primarily binds to TNFR1, leading to diverse cellular outcomes like apoptosis, proliferation, and gene activation. Anti-TNF agents are used to treat autoimmune and inflammatory disorders by neutralizing sTNF.
- Other names
- sTNFSoluble TNF alphasTNFa
02
Mechanism of action
Neutralization of soluble TNFα, preventing receptor binding and downstream signaling
03
Biological functions
Immune responseInflammationApoptosisSignal transductionAnti-tumor responseInfection control
04
Disease associations
Autoimmune diseasesInflammatory diseasesCancerInfections
05
Safety considerations
Increased risk of infectionsGranulomatous infections (with some anti-TNF agents)Potential for immune-related adverse events
06
Interacting drugs
Infliximab
2 more in the full profile.
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