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Target intelligence / Profile preview
Tumor Necrosis Factor-Alpha Convertase (TACE)
- Target
- TACE
- Molecular classification
- Metalloprotease, ADAM family of metalloproteases/disintegrins, Enzyme
01
Overview
Tumor necrosis factor-alpha convertase (TACE/ADAM17) is a critical regulator controlling bioavailability and function of soluble versus transmembrane forms of key cytokines like TNF-alpha. It plays essential roles in immunity but also contributes significantly to pathologies when dysregulated—making it an important drug target for various inflammatory diseases and cancer therapy development efforts.
- Other names
- ADAM17
02
Mechanism of action
Inhibition of TACE enzymatic activity, preventing the cleavage of transmembrane TNF-alpha into soluble TNF-alpha and other substrates.
03
Biological functions
Proteolytic cleavageRegulation of TNF-alpha bioavailabilityModulation of cell signalingImmune response
04
Disease associations
Inflammatory diseasesRheumatoid arthritisPsoriasisInflammatory bowel diseaseCardiovascular diseasesNeurodegenerative disordersCancer
05
Safety considerations
Potential for off-target effects due to broad substrate specificity of ADAM17Complete abolishment of all tmTNF functionInhibition of other ADAM17 substrates
06
Interacting drugs
TACE inhibitors (class of drugs)
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