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Target intelligence / Profile preview
Tumor necrosis factor alpha-induced interleukin 8 secretion
- Molecular classification
- Signaling pathway, Cytokine signaling cascade
01
Overview
Tumor necrosis factor alpha-induced interleukin 8 secretion is a signaling pathway activated by TNF-α binding to its receptors, leading to increased IL-8 (CXCL8) production. This process involves activation of NF-kB, MAPK, and PI3K/Akt pathways, resulting in neutrophil recruitment and inflammation. Dysregulation of this pathway is implicated in various chronic inflammatory diseases and cancer.
- Other names
- TNF-α-induced IL-8 secretionTumor necrosis factor alpha stimulated interleukin 8 productionTNF alpha-induced CXCL8 secretion
02
Mechanism of action
Inhibition of TNF-α signaling, Inhibition of IL-8/CXCL8 activity, Inhibition of downstream signaling pathways (NF-kB, MAPK, PI3K/Akt)
03
Biological functions
InflammationNeutrophil chemotaxisImmune responseCell signaling
04
Disease associations
Rheumatoid arthritisInflammatory bowel diseaseCancerPeriodontitisChronic inflammatory diseases
05
Safety considerations
ImmunosuppressionIncreased risk of infectionPotential for off-target effects
06
Interacting drugs
Anti-TNF therapies
4 more in the full profile.
07
Biomarkers
TNF-α levelsIL-8/CXCL8 levels
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