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Target intelligence / Profile preview
Tumor Necrosis Factor Alpha Receptor 1 (None)
- Target
- None
- Molecular classification
- Tumor Necrosis Factor Receptor Superfamily, Receptor
01
Overview
Tumor necrosis factor alpha receptor 1 (TNFR1) is a cell surface receptor that primarily binds tumor necrosis factor-alpha (TNF-α), a key cytokine involved in inflammation, immune regulation, and cell death. TNFR1 is part of the tumor necrosis factor receptor superfamily and plays a central role in mediating the biological effects of TNF-α, including pro-inflammatory signaling, apoptosis (programmed cell death), and regulation of immune responses. Aberrant or excessive activation contributes to chronic inflammatory diseases, autoimmune disorders, cancer progression or suppression depending on context, metabolic syndromes, neurodegeneration, among others.
- Other names
- p55CD120a
02
Mechanism of action
Selective modulation/inhibition of TNFR1 signaling
03
Biological functions
Signal transductionApoptosisImmune responseInflammationCell survival
04
Disease associations
InflammationAutoimmune disordersCancerMetabolic syndromesNeurodegenerative disease
05
Safety considerations
ImmunosuppressionPotential for off-target effects
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