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Target intelligence / Profile preview
Tumor Necrosis Factor Alpha Receptor 2 (TNFRII)
- Target
- TNFRII
- Molecular classification
- Receptor, Tumor Necrosis Factor Receptor Superfamily
01
Overview
Tumor necrosis factor alpha receptor 2 (TNFRII or TNFR2) is one of two primary membrane receptors for tumor necrosis factor-alpha (TNFα), a key cytokine in inflammation, immunity, and cell death. Signaling through TNFRII has anti-inflammatory activities and protective effects on certain nonimmune cells such as oligodendrocytes, cardiomyocytes, and keratinocytes. Preferentially stimulates regulatory T cells (Tregs).
- Other names
- TNFR2Tumor necrosis factor receptor superfamily member 1BTNFRSF1BCD120b
02
Mechanism of action
Agonists may boost Treg function for autoimmunity. Antagonists/blockers may enhance antitumor immunity by reducing suppressive Treg activity within tumors.
03
Biological functions
Signal transductionImmune responseCell survivalInflammationCell proliferationT cell regulation
04
Disease associations
Autoimmune diseasesCancerInflammationHeart failureMultiple sclerosis
05
Safety considerations
Potential for broad-spectrum anti-TNF therapies to block beneficial effects
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