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Tumor necrosis factor alpha secretion

Molecular classification: Cytokine-mediated signaling event

Overview

Tumor necrosis factor alpha secretion describes the regulated release—via proteolytic cleavage—of this central pro-inflammatory cytokine from various immune and nonimmune cell types. Once secreted in its active trimeric form(s), it binds specific surface receptors on target tissues triggering complex intracellular signaling cascades that mediate immunity but also drive pathology when dysregulated.

Other names: TNF-α secretion

Mechanism of action

N/A

Biological functions

Inflammation induction/regulationApoptosis/necroptosis inductionFever generationImmune response regulation

Disease associations

Autoimmune diseasesInflammatory disordersChronic inflammationTumorsCNS pathologies

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