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Target intelligence / Profile preview
Tumor Necrosis Factor Beta (TNF-β)
- Target
- TNF-β
- Molecular classification
- Cytokine, Tumor Necrosis Factor Superfamily, Ligand
01
Overview
Tumor necrosis factor beta (TNF-β), also known as lymphotoxin-alpha (LT-α), is a cytokine belonging to the tumor necrosis factor superfamily. It is primarily produced by activated lymphocytes and plays a critical role in immune regulation, development of lymphoid organs, and cytotoxicity against tumor cells. It signals through TNFR1 and TNFR2, influencing apoptosis and cell survival. Dysregulation contributes to chronic inflammation and cancer, making it a therapeutic target for autoimmune diseases.
- Other names
- Lymphotoxin-alphaLT-αTumor necrosis factor-betaMember: Tumor Necrosis Factor Superfamily
02
Mechanism of action
TNF inhibitors block the interaction of TNF-β with its receptors, TNFR1 and TNFR2, thereby reducing inflammation and immune responses.
03
Biological functions
Immune regulationCell survivalCell proliferationCell differentiationApoptosisCytotoxicityOrganogenesisNF-kappa B activation
04
Disease associations
Chronic inflammationCancerAutoimmune diseases
05
Safety considerations
Increased risk of infectionIncreased risk of certain cancersReactivation of latent tuberculosis
06
Interacting drugs
TNF inhibitors (e.g., Adalimumab, Infliximab, Etanercept)
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