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Target intelligence / Profile preview
Tumor Necrosis Factor Ligand Superfamily Member 10 (TNFSF10)
- Target
- TNFSF10
- Molecular classification
- Cytokine, Tumor Necrosis Factor Family Ligand, Ligand
01
Overview
Tumor necrosis factor ligand superfamily member 10 (TNFSF10), also known as TRAIL (TNF-related apoptosis-inducing ligand) and CD253, is a cytokine belonging to the tumor necrosis factor (TNF) ligand family. It plays a critical role in inducing apoptosis, particularly in tumor cells. It binds to death receptors (TRAILR1 and TRAILR2) to initiate apoptosis and decoy receptors (TRAILR3, TRAILR4, OPG) that modulate its activity. While it has shown promise as an anti-cancer therapeutic due to its selective ability to induce tumor cell death, clinical trials have yielded limited success.
- Other names
- TRAILApo2LApo2 ligandCD253
02
Mechanism of action
Induces apoptosis by binding to death receptors (TRAILR1/TNFRSF10A and TRAILR2/TNFRSF10B) on target cells.
03
Biological functions
ApoptosisImmune regulationCell death
04
Disease associations
CancerAnaplastic thyroid carcinomaColon adenocarcinomaPulmonary arterial hypertensionImmune disorders
05
Safety considerations
Limited survival benefit in clinical trials with direct targeting approaches.Potential for off-target effects.
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