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Target intelligence / Profile preview
Tumor necrosis factor ligand superfamily member 13 (APRIL)
- Target
- APRIL
- Molecular classification
- Cytokine, Tumor Necrosis Factor Ligand Superfamily
01
Overview
APRIL (Tumor necrosis factor ligand superfamily member 13) is a cytokine that plays key roles in immune regulation, particularly in B cell development and survival, especially long-term plasma cell survival. It acts as a ligand for BCMA and TACI receptors. Dysregulation is associated with autoimmune diseases, common variable immunodeficiency, and cancer, where it can act as an onco-inflammatory marker.
- Other names
- CD256TALL-2TALL2TRDL-1ZTNF2UNQ383/PRO715TNLG7Btumor necrosis factor superfamily member 13
02
Biological functions
B cell developmentB cell survivalPlasma cell survivalHumoral immunity regulationApoptosis
03
Disease associations
Autoimmune diseaseCommon variable immunodeficiencyCancer
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