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Target intelligence / Profile preview
Tumor Necrosis Factor Ligand Superfamily Member 13A (APRIL)
- Target
- APRIL
- Molecular classification
- Cytokine, Type II transmembrane protein, TNF superfamily ligand
01
Overview
Tumor necrosis factor ligand superfamily member 13A (APRIL) is a cytokine belonging to the TNF superfamily. It plays a significant role in immune regulation, particularly in B cell development and survival. APRIL binds to TACI and BCMA, regulating B cell development, immunoglobulin class switching, and plasma cell survival. Dysregulation is implicated in autoimmune diseases, cancer progression, and immunodeficiencies. Therapeutic targeting of APRIL or its receptors is under investigation.
- Other names
- TNFSF13A Proliferation-Inducing Ligand
02
Mechanism of action
Targeting APRIL or its receptors is under investigation for cancer and autoimmune conditions.
03
Biological functions
B cell developmentB cell survivalImmunoglobulin class switchingImmune regulationCell proliferationApoptosis
04
Disease associations
CancerAutoimmune disordersImmunodeficiencies
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