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Target intelligence / Profile preview
Tumor Necrosis Factor Ligand Superfamily Member 14 (TNFSF14)
- Target
- TNFSF14
- Molecular classification
- Tumor Necrosis Factor Ligand Superfamily, Type II transmembrane glycoprotein
01
Overview
Tumor Necrosis Factor Ligand Superfamily Member 14 (TNFSF14), also known as LIGHT or CD258, is a type II transmembrane glycoprotein belonging to the TNF ligand superfamily. It interacts with HVEM and LTβR receptors, playing a crucial role in costimulating immune cells, inducing apoptosis in tumor cells, and influencing vascular remodeling. LIGHT's involvement in anti-tumor immunity makes it a therapeutic target for cancer immunotherapy.
- Other names
- LIGHTCD258
02
Mechanism of action
Modulation of LIGHT pathway to enhance anti-tumor immunity, promote immune cell infiltration, and remodel tumor vasculature.
03
Biological functions
Costimulation of immune responseT cell activationNK cell activationApoptosis inductionVascular remodelingCytokine productionNFκB pathway activation
04
Disease associations
CancerInflammation
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