Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15)
- Target
- TNFSF15
- Molecular classification
- Cytokine, Tumor necrosis factor ligand superfamily
01
Overview
Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15), also known as TL1A and VEGI, is a cytokine primarily expressed in endothelial cells. It exists in both membrane-bound and soluble forms and is inducible by pro-inflammatory cytokines. TNFSF15 functions include activation of NF-kappa-B and MAPK signaling, inhibition of angiogenesis, induction of apoptosis, modulation of epithelial cell proliferation, macrophage polarization, and T-cell activation. It plays a significant role in immune responses and is associated with inflammatory bowel disease and systemic lupus erythematosus.
- Other names
- TL1AVEGIVascular Endothelial Growth InhibitorTNLG1BTNF superfamily member 15
02
Mechanism of action
Ligand binding activates downstream NF-kappa-B/MAPK pathways leading to immune modulation or apoptosis.
03
Biological functions
Activation of NF-kappa-B signaling pathwayActivation of MAPK signaling pathwayInhibition of vascular endothelial growthAntiangiogenic activityInduction of apoptosisModulation of epithelial cell proliferationMacrophage polarizationT-cell activationT-cell proliferationCytokine generationImmune response
04
Disease associations
Inflammatory Bowel DiseaseCrohn's diseaseSystemic Lupus Erythematosus
05
Biomarkers
Serum TNFSF15 levels in SLE
Beyond the preview
Go deeper on Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15).