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Target intelligence / Profile preview
Tumor Necrosis Factor-Like Weak Inducer of Apoptosis
- Molecular classification
- Cytokine, Tumor Necrosis Factor Superfamily, Ligand
01
Overview
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a cytokine belonging to the tumor necrosis factor (TNF) superfamily. It primarily signals through its receptor, fibroblast growth factor-inducible 14 (Fn14), regulating diverse cellular processes, including cell survival, apoptosis, angiogenesis, migration, and inflammation. The TWEAK/Fn14 axis is implicated in neurodegeneration, cardiovascular disease, metabolic syndrome, cancer, and inflammation.
- Other names
- TNFSF12
02
Mechanism of action
Blocking the TWEAK/Fn14 interaction using neutralizing antibodies
03
Biological functions
Cell survivalCell proliferationApoptosisAngiogenesisMigrationInflammationImmune response
04
Disease associations
NeurodegenerationCardiovascular diseaseMetabolic syndromeCancerInflammation
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