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Target intelligence / Profile preview
Tumor necrosis factor receptor 1 (TNFR1)
- Target
- TNFR1
- Molecular classification
- Receptor, Type I transmembrane protein
01
Overview
Tumor necrosis factor receptor 1 (TNFR1) is a type I transmembrane protein and a key receptor mediating the effects of TNFα. Upon ligand binding, it initiates diverse signaling pathways leading to inflammation, apoptosis, or necroptosis, depending on the cellular context. Its functions include activation of transcription factors such as NF-kB and regulation of immune responses, cell proliferation, survival, differentiation, and programmed cell death. Mutations in TNFRSF1A are associated with diseases like TRAPS and increased risk for multiple sclerosis.
- Other names
- tumor necrosis factor receptor superfamily member 1ATNFRSF1ACD120a
02
Mechanism of action
Modulation of TNFα signaling
03
Biological functions
Signal transductionApoptosisImmune responseCell proliferationCell survivalCell differentiationCell deathInflammatory responseNecroptosis
04
Disease associations
InflammationAutoimmune diseaseNeurodegenerative diseaseNeuropsychiatric DisordersAutoinflammatory disorder
05
Safety considerations
Potential for broad immunosuppressionRisk of infectionsExacerbation of demyelinating diseases
06
Biomarkers
Elevated serum levels in schizophrenia/bipolar disorderHigh serum levels associated with cognitive impairment/dementia risk
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