Tumor necrosis factor receptor 2 (TNFR2)

Tumor necrosis factor receptor 2 (TNFR2) is a membrane-bound receptor protein and a member of the tumor necrosis factor receptor superfamily. It contains four cysteine-rich domains in its extracellular region for ligand binding, primarily membrane-bound tumor necrosis factor-alpha (tmTNF). Unlike TNFR1, TNFR2 lacks an intracellular death domain and primarily signals for cell survival, proliferation, immune modulation, or tissue regeneration through activation of both canonical and non-canonical NF-κB pathways. TNFR2 is expressed on endothelial cells, fibroblasts, subsets of neurons, and immune cells, notably regulatory T cells and myeloid-derived suppressor cells. It is implicated in tumor progression, autoimmune diseases, and other conditions due to its dual pro-inflammatory/anti-inflammatory roles. Therapeutic strategies are being developed to selectively target the stimulatory or inhibitory functions of this receptor for cancer immunotherapy or treatment of autoimmune diseases.

Other names

TNFRSF1BCD120b

Modulation of NF-κB signaling pathways; Activation of regulatory T cells; Inhibition of immunosuppressive cells