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Target intelligence / Profile preview
Tumor Necrosis Factor Receptor-Associated Factor (TRAF)
- Target
- TRAF
- Molecular classification
- Adaptor protein, E3 ubiquitin ligase (TRAF6), RING finger protein
01
Overview
Tumor necrosis factor receptor-associated factors (TRAFs) are a family of structurally related intracellular adaptor proteins that play central roles in signal transduction from members of the tumor necrosis factor receptor (TNFR) superfamily and various other immune receptors. They regulate inflammation, antiviral responses, apoptosis, and cell survival. Dysregulation or mutation within this family is implicated in autoimmune/inflammatory diseases, immunodeficiency, and cancer progression.
02
Mechanism of action
TRAFs function as adaptor proteins by associating with the cytoplasmic tails of activated receptors, mediating downstream signaling events like the activation of NF-κB and MAPK pathways.
03
Biological functions
Signal transductionRegulation of NF-κB signalingRegulation of MAPK signalingInflammationAntiviral responseApoptosisCell survivalImmune response
04
Disease associations
Autoimmune diseasesInflammatory diseasesImmunodeficiencyCancer
05
Safety considerations
Dysregulation can lead to chronic inflammation or impaired host defense.Mutations can alter immune homeostasis.
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