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Target intelligence / Profile preview
Tumor Necrosis Factor Receptor-Associated Protein 1 (TRAP1)
- Target
- TRAP1
- Molecular classification
- Heat shock protein, Hsp90 family, Mitochondrial chaperone
01
Overview
Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial chaperone belonging to the heat shock protein 90 (Hsp90) family. It plays a critical role in maintaining mitochondrial proteostasis, regulating reactive oxygen species (ROS) levels, and modulating apoptosis. TRAP1 is overexpressed in many tumor types and supports cancer cell survival under stress conditions. It has also been implicated in neurodegenerative diseases, particularly Parkinson's disease, where it protects against mitochondrial dysfunction.
- Other names
- HSP75Heat shock protein 75 kDaTNFRAP1
02
Mechanism of action
Inhibition of TRAP1 activity to disrupt mitochondrial function and induce apoptosis in cancer cells. Modulation of TRAP1 phosphorylation to impact neuroprotection.
03
Biological functions
Chaperone activityCellular stress responseRegulation of apoptosisMetabolic regulationRegulation of reactive oxygen species (ROS) levelsProtein folding
04
Disease associations
CancerNeurodegenerative diseaseParkinson's disease
05
Safety considerations
Potential for off-target effects due to the broad chaperone function of TRAP1.Complex role in different tissues (pro-tumorigenic vs. anti-metastatic).
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