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Target intelligence / Profile preview
Tumor necrosis factor receptor II (TNFR2)
- Target
- TNFR2
- Molecular classification
- Receptor, Tumor necrosis factor receptor superfamily (TNFRSF), Type I transmembrane protein
01
Overview
Tumor Necrosis Factor Receptor II is a type I transmembrane protein that binds primarily membrane-bound forms of its ligand TNFα. It lacks an intracellular death domain but plays crucial roles in regulating cell survival/proliferation versus indirect induction of cell death through modulation of key adaptor proteins.
- Other names
- TNFRSF1BCD120bp75
02
Mechanism of action
Modulation of TNFR2 signaling, including blocking or agonistic approaches.
03
Biological functions
Cell survivalCell proliferationInflammatory responseImmune modulationApoptosisSignal transduction
04
Disease associations
CancerNeuroprotection
05
Safety considerations
Potential for immune-related adverse events due to modulation of immune cell function.Dual roles in immunity and inflammation require careful consideration of context-specific effects.
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