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Target intelligence / Profile preview
Tumor Necrosis Factor Receptor Superfamily Member 10B (DR5)
- Target
- DR5
- Molecular classification
- Receptor, Transmembrane protein, TNF-receptor superfamily
01
Overview
Tumor Necrosis Factor Receptor Superfamily Member 10B (DR5) is a death domain-containing transmembrane receptor that triggers apoptosis upon binding to TRAIL. Activation of DR5 recruits FADD, leading to caspase-8 activation and programmed cell death. DR5 is a promising therapeutic target for cancer due to its ability to selectively induce apoptosis in malignant cells.
- Other names
- TRAIL receptor 2TRAILR2TNFRSF10BCD262KILLERTRICK2A/BApo2Fas-like proteinZTNFR9
02
Mechanism of action
DR5 agonists induce apoptosis via activation of caspase cascade.
03
Biological functions
ApoptosisSignal transductionNF-kappaB signalingResponse to endoplasmic reticulum stressMulticellular organism developmentRegulation of immune responses
04
Disease associations
Cancer
05
Safety considerations
Potential off-target effects on normal tissues.
06
Interacting drugs
Tigatuzumab
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