Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D)

Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), also known as Decoy receptor 2 (DCR2) or TRAIL receptor 4 (TRAILR4), is a cell surface receptor belonging to the TNF receptor superfamily[1][3][7]. Unlike related pro-apoptotic receptors, TNFRSF10D contains a truncated cytoplasmic death domain, rendering it incapable of inducing apoptosis; instead, it acts as a decoy receptor that binds TRAIL, thereby inhibiting TRAIL-induced cell death and modulating immune and apoptotic responses[1][3][4][6]. TNFRSF10D is implicated in a range of cancers, both as a marker of tumor progression and as a regulator of tumor sensitivity to TRAIL-based therapies, with its epigenetic silencing associated with tumorigenesis in several cancer types[1][2].

Other names

Decoy receptor 2TRAIL receptor 4TRAILR4DCR2CD264TRUNDD

Acts as a decoy receptor for TRAIL (TNF-related apoptosis-inducing ligand), inhibiting TRAIL-induced apoptosis by competing with pro-apoptotic TRAIL receptors for ligand binding[1][3][4][6].