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Target intelligence / Profile preview
Tumor necrosis factor receptor superfamily member 12A
- Molecular classification
- Receptor, Tumor Necrosis Factor Receptor Superfamily
01
Overview
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A), also known as TWEAK receptor (TWEAKR) or fibroblast growth factor-inducible 14 (FN14), is a receptor for TWEAK. It is involved in several biological processes including inflammation, angiogenesis, cell proliferation, migration, and apoptosis. It is considered a drug target due to its proinflammatory profile and involvement in various diseases.
- Other names
- TWEAK receptorTWEAKRFibroblast growth factor-inducible 14FN14
02
Mechanism of action
Anti-TWEAK receptor monoclonal antibody
03
Biological functions
Inflammatory reactionsAngiogenesisCell proliferationCell migrationCell death/apoptosis regulationModulates expression of NF-kB-regulated genesPositive regulation of extrinsic apoptotic signaling pathwaysWound healing processes
04
Disease associations
GlioblastomaMultiple SclerosisColorectal CancerPancreatic CancerMuscle AtrophyCerebral IschemiaKidney InjuryAtherosclerosisInfarctionAutoimmune DiseasesRheumatoid arthritisInflammatory bowel diseaseAutoimmune encephalitis
05
Interacting drugs
PDL192
1 more in the full profile.
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